Table 1.
Cumulative annualized incidence rates for clinical outcomes in the WHI CEE-alone trial by 10 year age stratification at enrollment.a
| No. (%) of Eventsevents | ||||
|---|---|---|---|---|
| Event by Age age Groupgroup, y | CEE | Placebo | HR (95% CI) | P Value value for Interactioninteraction |
| CHD | ||||
| 50–59 | 33 (0.18) | 56 (0.31) | 0.59 (0.38–0.90) | |
| 60–69 | 161 (0.65) | 168 (.065) | 1.00 (0.80–1.24) | .05 |
| 70–79 | 125 (1.01) | 121 (0.95) | 1.06 (0.82–1.36) | |
| Total MI | ||||
| 50–59 | 27 (0.15) | 50 (0.27) | 0.54 (0.34–0.86) | |
| 60–69 | 126 (0.51) | 124 (0.48) | 1.05 (0.82–1.35) | .007 |
| 70–79 | 101 (0.82) | 84 (0.66) | 1.23 (0.92–1.65) | |
| Stroke | ||||
| 50–59 | 29 (0.16) | 28 (0.15) | 1.09 (0.65–1.83) | |
| 60–69 | 114 (0.46) | 94 (0.36) | 1.27 (0.97–1.67) | .91 |
| 70–79 | 92 (0.74) | 84 (0.66) | 1.13 (0.84–1.53) | |
| Death (all causes) | ||||
| 50–59 | 65 (0.35) | 89 (0.48) | 0.73 (0.53–1.00) | |
| 60–69 | 254 (1.00) | 253 (0.96) | 1.04 (0.88–1.24) | .04 |
| 70–79 | 258 (2.02) | 239 (1.83) | 1.12 (0.94–1.33) | |
a
Modified from Figure Fig. 5 of reference [10•]. The rates were estimated for the overall follow-up period (intervention mean 7.1, follow-up median 5.9 years). P values are for interaction by age.
Abbreviations: CEE, conjugated equine estrogen; CHD, coronary heart disease; WHI, Women’s Health Initiative.