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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Int Rev Phys Chem. 2012 Dec 24;32(1):10.1080/0144235X.2012.751175. doi: 10.1080/0144235X.2012.751175

Figure 9.

Figure 9

Summary of the effects of phosphorylation on Abl SH3 unfolding for various constructs. (A). Comparison of slowdown factor of free SH3 and SH3 incubated with BP1, both with and without phosphorylation by Hck. When Hck is present (as indicated with the -/+ symbols) Abl is phosphorylated at the positions indicated (see also [84]) by the blue dots in the cartoons at the bottom – Tyr89 (in SH3) and Tyr245 (in the SH2-kinase linker). (B). Comparison of slowdown factor as a function of phosphorylation in the constructs indicated. Mutants are indicated, with dYF being the double mutant of Y89F,Y245F. This figure is taken from Ref. [84].