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. 2013 May 13;4:80. doi: 10.3389/fgene.2013.00080

Figure 1.

Figure 1

TP53INP1 induces p53 protein phosphorylation at Ser-46 and apoptosis after DNA damage. Upon initial DNA damage, p53 is phosphorylated at Ser-15 and Ser-20, stimulating the binding of p53 to the promoter regions of a subset of genes such as the G1 arrest gene p21, the DNA repair gene p53R2 and p53 negative regulators. If DNA damage is severe, TP53INP1 forms protein complexes with the Ser-46 kinase HIPK2 and PKCδ, leading to p53 protein phosphorylation at Ser-46, induction of p53AIP1 gene transcription and apoptosis.