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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Cancer Res. 2013 Feb 1;73(7):2117–2126. doi: 10.1158/0008-5472.CAN-12-3957

Figure 2. Preneoplastic lesions in TxA23 mice.

Figure 2

(A) Pathology scores of stomach sections from 2 month old (N=9) and 4 month old TxA23 mice (N=19). (B-D) Representative images of pathology observed in TxA23 mice illustrating (B) inflammation, oxyntic atrophy, and mucosal hyperplasia. (C) Extensive parietal cell loss accompanied by moderate levels of mucinous metaplasia (red bracket). (D) Focal regions of mild dysplasia (blue bracket). (E) Normal morphology in a BALB/c control mouse with healthy parietal cells and basal non-metaplastic zymogenic chief cells at base of unit (red bracket denotes base region). Arrows point to healthy parietal cells. Statistics were performed using the Mann-Whitney U Test (** p < 0.01, *** p < 0.001).