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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Leukemia. 2012 Sep 21;27(3):702–710. doi: 10.1038/leu.2012.272

Figure 1.

Figure 1

MΦs mediate MM multidrug resistance. Shown are percentages of melphalan (mel; 15 μM)-induced apoptotic MM cells in (a) different culture conditions; culture alone, transwell coculture with MΦs, direct coculture with MΦs, and transwell coculture with ARP-1/MΦs; (b) direct coculture with MΦs with different MΦ/MM ratios; and (c) direct coculture with MΦs after different doses of melphalan (5–15 μM) treatment. (d) Melphalan (15 μM)-induced apoptotic ARP-1 cells in direct cocultures with healthy donor monocytes (ex vivo precultured for 1 day) or MΦs. (e) Percentages of bortezomib (BTZ, 10 nM)-induced apoptotic ARP-1, ARK and CAG cells in direct cocultures with MΦs. (f) Percentages of doxorubicin (Doxo, 25 ng/ml)-induced apoptotic ARP-1, ARK and CAG cells in direct cocultures with MΦs. Summarized results from three independent experiments are shown. *P<0.05, **P<0.01.

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