Figure 2.

MΦ is an effective protector cell in MM–BM. (a) A representative flow cytometry analysis showing the percentages of mDCs, pDCs and MΦs in the BM aspirate of a MM patients’; and (b) summarized results of the percentages of these cells in the BM aspirates of 10 MM patients’ samples. Numbers indicate the mean percentages. Also shown are percentages of melphalan (15 μM)-induced apoptotic ARP-1 cells in cocultures (transwell coculture or direct coculture) with (c) MM patients’ monocyte-derived MΦs and (d) primary CD14⁺/CD163⁺ MΦs (primary MΦs; pri. MΦs) isolated from the BM of MM patients’s. In (c) and (d), the representative results using primary MM samples from one out of three patients’s are shown. Summarized results from three independent experiments are shown. *P<0.05, **P<0.01.