Table 4.
Associations between genetic summary score, BMI, physical activity, and diet and risk of colon and rectal cancer
| Controls | Cases | Controls | Cases | Controls | Cases | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary Scores | N | N | OR | (95% CI) | N | N | OR | (95% CI) | N | N | OR | (95% CI) | |
| Genotypes | BMI | ||||||||||||
| Normal (<25) | Overweight (25–29) | Obese (30+) | |||||||||||
| Colon | (17 – 30) | 105 | 27 | 1.00 | 112 | 63 | 2.18 | (1.29,3.68) | 58 | 27 | 1.77 | (0.94,3.30) | |
| (31 – 38) | 419 | 237 | 2.21 | (1.41,3.48) | 443 | 261 | 2.28 | (1.45,3.58) | 211 | 179 | 3.29 | (2.05,5.25) | |
| (39 – 43) | 165 | 166 | 3.99 | (2.48,6.43) | 169 | 197 | 4.50 | (2.81,7.22) | 106 | 142 | 5.21 | (3.18,8.53) | |
| (44 – 56) | 69 | 74 | 4.24 | (2.48,7.26) | 72 | 109 | 6.01 | (3.57,10.10) | 23 | 68 | 11.38 | (6.02,21.51) | |
| Rectal | (4 – 11) | 76 | 26 | 1.00 | 88 | 35 | 1.12 | (0.62,2.04) | 52 | 23 | 1.25 | (0.64,2.43) | |
| (12 – 15) | 116 | 93 | 2.30 | (1.36,3.88) | 172 | 114 | 1.86 | (1.12,3.09) | 101 | 75 | 2.08 | (1.22,3.57) | |
| (16 – 19) | 94 | 85 | 2.62 | (1.53,4.48) | 118 | 100 | 2.37 | (1.41,4.00) | 58 | 78 | 3.76 | (2.14,6.61) | |
| (20 – 28) | 25 | 39 | 4.49 | (2.29,8.80) | 30 | 53 | 4.91 | (2.60,9.27) | 24 | 28 | 3.21 | (1.58,6.51) | |
| Physical Activity | |||||||||||||
| Low | Intermediate | High | |||||||||||
| Colon | (17 – 30) | 81 | 34 | 1.00 | 104 | 43 | 0.99 | (0.58,1.70) | 91 | 40 | 1.06 | (0.61,1.84) | |
| (31 – 38) | 296 | 228 | 1.91 | (1.23,2.96) | 374 | 233 | 1.50 | (0.97,2.33) | 405 | 217 | 1.28 | (0.82,1.98) | |
| (39 – 43) | 131 | 180 | 3.45 | (2.17,5.47) | 157 | 184 | 2.81 | (1.78,4.43) | 152 | 144 | 2.30 | (1.44,3.66) | |
| (44 – 56) | 43 | 77 | 4.54 | (2.62,7.87) | 60 | 95 | 3.91 | (2.33,6.57) | 62 | 80 | 3.06 | (1.81,5.17) | |
| Rectal | (4 – 11) | 39 | 25 | 1.00 | 77 | 26 | 0.51 | (0.26,0.99) | 100 | 33 | 0.49 | (0.26,0.93) | |
| (12 – 15) | 88 | 72 | 1.28 | (0.71,2.31) | 143 | 97 | 0.99 | (0.56,1.75) | 161 | 113 | 1.03 | (0.58,1.80) | |
| (16 – 19) | 59 | 85 | 2.26 | (1.23,4.14) | 86 | 86 | 1.51 | (0.84,2.72) | 127 | 95 | 1.08 | (0.61,1.92) | |
| (20 – 28) | 15 | 34 | 3.54 | (1.60,7.81) | 31 | 44 | 2.06 | (1.04,4.09) | 33 | 44 | 1.93 | (0.98,3.81) | |
| Western Diet | |||||||||||||
| Low | Intermediate | High | |||||||||||
| Colon | (17 – 30) | 60 | 21 | 1.00 | 143 | 57 | 1.11 | (0.62,2.00) | 73 | 39 | 1.49 | (0.79,2.81) | |
| (31 – 38) | 241 | 117 | 1.35 | (0.79,2.34) | 576 | 363 | 1.79 | (1.07,3.00) | 258 | 198 | 2.18 | (1.27,3.71) | |
| (39 – 43) | 117 | 78 | 1.90 | (1.07,3.39) | 228 | 284 | 3.56 | (2.09,6.03) | 95 | 146 | 4.32 | (2.46,7.59) | |
| (44 – 56) | 35 | 39 | 3.09 | (1.57,6.08) | 96 | 139 | 4.26 | (2.42,7.48) | 34 | 74 | 6.09 | (3.19,11.63) | |
| Rectal | (4 – 11) | 62 | 16 | 1.00 | 94 | 94 | 33 | 1.35 | (0.69,2.67) | 60 | 35 | 2.18 | (1.09,4.37) |
| (12 – 15) | 107 | 68 | 2.43 | (1.30,4.57) | 169 | 114 | 2.58 | (1.41,4.70) | 116 | 100 | 3.22 | (1.73,5.97) | |
| (16 – 19) | 87 | 65 | 2.85 | (1.51,5.40) | 119 | 126 | 4.01 | (2.19,7.36) | 66 | 75 | 4.26 | (2.23,8.14) | |
| (20 – 28) | 25 | 32 | 4.81 | (2.25,10.28) | 31 | 46 | 5.60 | (2.74,11.47) | 23 | 44 | 7.14 | (3.37,15.12) | |
| Prudent Diet | |||||||||||||
| Low | Intermediate | High | |||||||||||
| Colon | (17 – 30) | 63 | 26 | 1.00 | 140 | 66 | 1.07 | (0.62,1.85) | 73 | 25 | 0.78 | (0.41,1.48) | |
| (31 – 38) | 229 | 183 | 1.92 | (1.17,3.17) | 587 | 336 | 1.33 | (0.83,2.15) | 259 | 159 | 1.36 | (0.83,2.25) | |
| (39 – 43) | 114 | 142 | 3.00 | (1.78,5.06) | 225 | 269 | 2.79 | (1.70,4.56) | 101 | 97 | 2.16 | (1.26,3.70) | |
| (44 – 56) | 36 | 57 | 3.91 | (2.10,7.27) | 91 | 138 | 3.56 | (2.09,6.06) | 38 | 57 | 3.37 | (1.81,6.26) | |
| Rectal | (4 – 11) | 68 | 35 | 1.00 | 93 | 28 | 0.56 | (0.31,1.01) | 55 | 21 | 0.70 | (0.37,1.35) | |
| (12 – 15) | 99 | 93 | 1.81 | (1.10,2.98) | 176 | 125 | 1.32 | (0.83,2.11) | 117 | 64 | 0.99 | (0.59,1.65) | |
| (16 – 19) | 96 | 86 | 1.71 | (1.03,2.82) | 121 | 105 | 1.61 | (0.99,2.63) | 55 | 75 | 2.49 | (1.45,4.27) | |
| (20 – 28) | 26 | 40 | 2.92 | (1.54,5.55) | 32 | 50 | 2.88 | (1.57,5.27) | 21 | 32 | 2.72 | (1.36,5.42) | |
| Calcium Intake | |||||||||||||
| Low | Intermediate | High | |||||||||||
| Colon | (17 – 30) | 65 | 25 | 1.00 | 143 | 72 | 1.31 | (0.76,2.25) | 68 | 20 | 0.77 | (0.39,1.53) | |
| (31 – 38) | 265 | 185 | 1.81 | (1.10,2.98) | 537 | 323 | 1.58 | (0.97,2.56) | 273 | 170 | 1.66 | (1.01,2.75) | |
| (39 – 43) | 126 | 144 | 3.02 | (1.79,5.08) | 211 | 259 | 3.25 | (1.98,5.35) | 103 | 105 | 2.67 | (1.56,4.57) | |
| (44 – 56) | 48 | 67 | 3.70 | (2.04,6.70) | 84 | 123 | 3.94 | (2.29,6.77) | 33 | 62 | 4.89 | (2.61,9.18) | |
| Rectal | (4 – 11) | 53 | 14 | 1.00 | 109 | 47 | 1.59 | (0.80,3.15) | 54 | 23 | 1.54 | (0.71,3.32) | |
| (12 – 15) | 83 | 63 | 2.79 | (1.42,5.47) | 211 | 140 | 2.43 | (1.30,4.56) | 98 | 79 | 2.90 | (1.50,5.64) | |
| (16 – 19) | 73 | 79 | 4.01 | (2.05,7.84) | 129 | 130 | 3.70 | (1.95,7.01) | 70 | 57 | 2.92 | (1.46,5.81) | |
| (20 – 28) | 16 | 30 | 6.98 | (2.99,16.29) | 37 | 63 | 6.13 | (2.99,12.56) | 26 | 29 | 3.99 | (1.80,8.84) | |
| Dietary Fiber Intake | |||||||||||||
| Low | Intermediate | High | |||||||||||
| Colon | (17 – 30) | 61 | 34 | 1.00 | 161 | 55 | 0.58 | (0.34,0.98) | 54 | 28 | 0.87 | (0.47,1.63) | |
| (31 – 38) | 278 | 195 | 1.23 | (0.78,1.94) | 553 | 332 | 1.04 | (0.67,1.62) | 244 | 151 | 1.06 | (0.66,1.69) | |
| (39 – 43) | 118 | 138 | 2.06 | (1.26,3.35) | 222 | 260 | 2.04 | (1.29,3.23) | 100 | 110 | 1.89 | (1.14,3.12) | |
| (44 – 56) | 46 | 62 | 2.35 | (1.33,4.16) | 84 | 122 | 2.62 | (1.58,4.34) | 35 | 68 | 3.26 | (1.81,5.87) | |
| Rectal | (4 – 11) | 56 | 26 | 1.00 | 93 | 35 | 0.79 | (0.43,1.46) | 67 | 23 | 0.70 | (0.36,1.37) | |
| (12 – 15) | 74 | 83 | 2.36 | (1.35,4.14) | 191 | 121 | 1.32 | (0.79,2.23) | 127 | 78 | 1.25 | (0.72,2.17) | |
| (16 – 19) | 85 | 71 | 1.77 | (1.01,3.11) | 121 | 132 | 2.26 | (1.33,3.83) | 66 | 63 | 1.97 | (1.10,3.53) | |
| (20 – 28) | 17 | 32 | 4.05 | (1.91,8.59) | 39 | 55 | 2.87 | (1.54,5.35) | 23 | 35 | 3.09 | (1.52,6.25) | |
Adjusted for age, center, race, and sex.