Distribution and alignment of various motifs of FMO proteins. A, schematic drawing of the location of the five motifs along fish FMO proteins. The motifs are shown relative to rainbow trout hFMO. B, alignment of the motifs showing the exact amino acid numbering and the deviation from the consensus shown on the top of the alignment. The shaded residues are identical to the consensus. Brare 5, Danio rerio (Q5RGM4); Tetni, Tetraodon nigroviridis (Q4T8R2); Frugu, Takifugu rubripes (Q802T5); Brare 1, D. rerio (Q5TZD0); Homsa 1, Homo sapiens (Q01740); Homsa 3, H. sapiens (P49326); Homsa 5, H. sapiens (P49326).