France; Sept–Dec 2002 |
Dendritic or geographic ulcer (epithelial), stromal keratitis with identical previous events, and subjective description by investigators (low, medium, or high probability of herpetic origin) |
New and recurrent epithelial keratitis in 22.0 per 100,000 person-years |
None noted during study period (3 months) |
Well-defined nationwide multicenter study with large number of randomized investigators reducing possibility of referral bias |
Potential seasonal effect on keratitis incidence |
New and recurrent stromal keratitis in 9.2 per 100,000 person-years |
Keratitis in 0.3 per 100,000 person-years that could not be classified |
New and recurrent epithelial and stromal keratitis cases that were “highly probable” in 25.8 per 100,00 person-years |
Rochester, MN (USA); 1950–1982 |
Punctate keratitis, dendritic or geographic ulcer (epithelial), or disciform/necrotizing keratitis (stromal) |
New and recurrent epithelial keratitis in 15.6 per 100,000 person-years |
Statistically insignificant rise in incidence during study period, possibly related to changing HSV-1 seroprevalence |
Well-defined long-term study data from single center that serves all of Rochester reducing possibility of referral bias |
Data from single center serving mostly white patients |
New and recurrent stromal keratitis in 2.6 per 100,000 person-years |
Funen, Denmark; 1976–1978 |
Epithelial dendritic ulcer |
Epithelial dendritic keratitis in 12 per 100,000 person-years |
None noted during study period (24 months) |
All cases in Funen that presented to an ophthalmologist were included (population 446,223) virtually eliminating referral bias |
Only cases of epithelial dendritic keratitis included |
Copenhagen, Denmark; (study dates not reported) |
Epithelial dendritic ulcer |
Epithelial dendritic keratitis in 5.9 per 100,000 person-years |
None noted during study period (7 years) |
Long-term study data from single center |
Only cases of epithelial dendritic keratitis included, many cases seen in the community likely not included |
Tunisia; Oct 1972– June 1973 |
Dendritic or geographic ulcer (epithelial) |
Epithelial keratitis in 1.4 per 100,000 person-years |
None noted during study period (8 months) |
Record-keeping included extraocular herpetic lesions and previous treatment |
Only epithelial keratitis incidence determined, no efforts made to include all cases from l’Institute d’Ophthalmologie de Tunis, no other centers included |
Rijeka, Croatia; (study dates not reported) |
Keratitis |
Keratitis in 4 per 100,000 person-years |
None noted during study period (18 years) |
Long-term study performed at single center |
Methodology and results not well-described |