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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Surv Ophthalmol. 2012 Apr 28;57(5):448–462. doi: 10.1016/j.survophthal.2012.01.005

TABLE 9.

HSV and Resistance to Acyclovir

Author(s) Method Results
Duan et al19 qPCR confirmed by plaque reduction assay 6.4% resistance in immunocompetent patients with herpetic keratitis
Stránská et al79 ELVIRA HSV screening assay 0.27% resistance in immunocompetent and 7% resistance in immunocompromised patients
Danve-Szatanek et al15 Chessboard technique 0.3% resistance in immunocompetent and 3.6% resistance in immunocompromised patients, with highest resistance in bone marrow transplant (10.9%)
Reyes et al71 Plaque reduction assay 0.1% resistance in immunocompetent patients
Gnann et alD Plaque reduction assay 5.6% resistance in immunocompromised patients
Christophers et al13 Plaque reduction assay 0.1–0.7% resistance in immunocompetent and 6.3% resistance in immunocompromised patients

ELVIRA = enzyme linked virus inhibitor reporter assay; qPCR = quantitative polymerase chain reaction.