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. Author manuscript; available in PMC: 2013 May 13.
Published in final edited form as: Nat Genet. 2011 Jun 5;43(7):621–629. doi: 10.1038/ng.848

Figure 4. Validated expression of ncRNAs in cell cycle progression, ES cell differentiation, and human cancers.

Figure 4

Custom Taqman probes were generated and used to interrogate independent biological samples for lncRNA expression. Periodic expression of lncRNAs (blue) during synchronized cell cycle progression in HeLa cells (a) and foreskin fibroblasts (b). Cell cycle phases are confirmed by FACS and expression of genes with known periodic expression in the cell cycle (orange).

(c) Regulated expression of lncRNAs in human ES cells vs. fetal pancreas.

(d) Differential expression of lncRNAs in normal breast epithelium vs. breast cancer.