Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2013 Oct 1.

Published in final edited form as: J Allergy Clin Immunol. 2012 Sep 1;130(4):932–44.e12. doi: 10.1016/j.jaci.2012.07.032

Fig 3 — Inhibition of Pim1 kinase reduces intestinal responses. A, Kinetics of development of diarrhea. The incidence of diarrhea was significantly lower in inhibitor (100 mg/kg)-treated WT mice than in Runx3^+/− mice (P< .05). B, Symptom scores were assessed 30 minutes after oral challenge. C, Plasma histamine levels were assessed within 30 minutes of the last oral challenge. D-G, Quantitation of mucosal mast cells, eosinophils, goblet cells, and CD4 and CD8 T cell numbers in the jejunum. Results were from 3 independent experiments; each experiment included 4 mice per group. *P< .05, **P< .01, and †P< .001. PBS/PE, Sham sensitized but PE challenged; PE/PE, PE sensitized and challenged.

Fig 3 — Inhibition of Pim1 kinase reduces intestinal responses. A, Kinetics of development of diarrhea. The incidence of diarrhea was significantly lower in inhibitor (100 mg/kg)-treated WT mice than in Runx3^+/− mice (P< .05). B, Symptom scores were assessed 30 minutes after oral challenge. C, Plasma histamine levels were assessed within 30 minutes of the last oral challenge. D-G, Quantitation of mucosal mast cells, eosinophils, goblet cells, and CD4 and CD8 T cell numbers in the jejunum. Results were from 3 independent experiments; each experiment included 4 mice per group. *P< .05, **P< .01, and †P< .001. PBS/PE, Sham sensitized but PE challenged; PE/PE, PE sensitized and challenged.