Fig 4.

Effect of Pim1 kinase inhibition on cytokine and transcription factor expression. A, T_H1, T_H2, and T_H17 mRNA expression in jejunums of WT and Runx3^+/− mice treated with AR460770 or vehicle. B, T_H1, T_H2, and T_H17 transcription factor expression in jejunums of WT and Runx3^+/− mice treated with AR460770 or vehicle. ROG, Repressor of GATA. C, Percentages of IFN-_γ⁺–, IL-4⁺–, IL-13⁺–, and IL-17A⁺–producing MLN CD3⁺CD4⁺ cells of WT and Runx3^+/− mice treated with the inhibitor or vehicle. Data are from 3 independent experiments (n = 12). *P < .05 and **P < .01. PBS/PE, Sham sensitized but PE challenged; PE/PE, PE sensitized and challenged.