Table 1. Diffusion tensor imaging and morphometric data for SHRSP and WKY.
| WKYa | SHRSPa | P valueb | |
|---|---|---|---|
| DTI data | |||
| FA, caudate nuclei | 0.277 (0.025) | 0.263 (0.020) | 0.345 |
| MD, caudate nuclei (mm2/s × 10−3) | 0.760 (0.011) | 0.732 (0.011) | 0.0019** |
| FA, corpus callosum | 0.610 (0.024) | 0.649 (0.032) | 0.035* |
| MD, corpus callosum (mm2/s × 10−3) | 0.985 (0.084) | 0.846 (0.041) | 0.016* |
| Histological data | |||
| MBP-positive area fraction (%): corpus callosum | 47.3 (5.6) | 67.7 (6.8) | <0.001*** |
| MBP-positive bundle cross section area: caudate nuclei (μm2) | 1710 (630) | 1020 (270) | 0.043* |
| MBP-positive bundle density: caudate nuclei (bundles/mm2) | 146 (40) | 207 (50) | 0.019* |
| Olig2-positive cells per mm2 | 1480 (120) | 1760 (470) | 0.084 |
| Fraction of cells positive for Olig2 (%) | 46.8 (9.9) | 48.1 (8.0) | 0.81 |
| Sclerotic index: large leptomeningeal arteries | 0.26 (0.03) | 0.31 (0.04) | 0.032* |
| SMA-positive area fraction (%): large leptomeningeal arteries | 63.9 (15.4) | 45.9 (12.7) | 0.038* |
| Sclerotic index: deep penetrating arterioles, caudate nuclei | 0.48 (0.09) | 0.44 (0.11) | 0.44 |
DTI, diffusion tensor imaging; FA, fractional anisotropy; MBP, myelin basic protein; MD, mean diffusivity; SHRSP, stroke-prone spontaneously hypertensive rats; SMA, smooth muscle actin.
*P<0.05, **P< 0.01, ***P<0.001.
a
Data are expressed as mean (s.d.).
b
Student's unpaired t-test.