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. 2013 Jan 30;33(5):708–715. doi: 10.1038/jcbfm.2013.1

Figure 3.

Figure 3

Hyperhomocysteinemia (HHCy) is associated with microglial activation. (A–H) CD11b immunohistochemistry in the frontal cortex (A–D) and hippocampus (E–H) of wild-type mice receiving control diet (A–B and E–F) or experimental diet (C–D and G–H) is shown. (A, C, E, G) Magnification= × 4, scale bar in (A) for (A), (C), (E), and (G)=120 μm. (B, D, F, H) Magnification= × 200, scale bar in (B) for (B), (D), (F), and (H)=25 μm. (B, D, F, H) High magnification images of (A), (C), (E), and (G), respectively. (I) Quantification of percent area occupied by positive stain for CD11b in the frontal cortex (FCX), CA3, and dentate gyrus (DG) of the hippocampus and the entorhinal cortex (EnCX). *Indicates P<0.05 and **indicates P<0.01 by t-test.