Table 2. The percentage ¹³C enrichment of metabolites in cerebral cortex.

	Cerebral cortex
	Control	pR5	P value
[3-13C]lactate	3.9±0.4	5.0±0.5	0.117
[3-13C]alanine	3.5±0.4	4.3±0.6	0.315
[2-13C]glutamate	1.1±0.2	1.9±0.1**	0.006
[3-13C]glutamate	1.2±0.2	1.7±0.1*	0.014
[2-13C]glutamine	0.8±0.2	1.5±0.2**	0.007
[3-13C]glutamine	1.5±0.2	2.2±0.2*	0.029
[3-13C]GABA	1.7±0.2	2.3±0.2*	0.043
[4-13C]GABA	1.7±0.3	2.6±0.3*	0.032
[3-13C]aspartate	2.2±0.2	2.9±0.3	0.102

The percentage ¹³C enrichment of metabolites in the cerebral cortex of control (n=7) and pR5 (n=8) mice. Results are presented as average±s.e.m. The mice were injected with [1-¹³C]glucose and [1,2-¹³C]acetate, for details see Materials and Methods.

*P<0.05.

**P<0.01, statistically significant difference between control and pR5 mice calculated using the Student's t test.