Table 5.
Contribution of Class I and II HLA alleles to development of ACL in a Southern Brazilian population
|
Allele |
ACL |
Controls (n = 260) |
P-value |
Pc-value |
OR |
95%CI |
||
|---|---|---|---|---|---|---|---|---|
| n | F % | n | F % | |||||
|
ACL overall (n = 169) |
|
|
|
|
|
|
|
|
| HLA-B*45 |
0 |
- |
12 |
2.3 |
0.0046 |
0.1426 |
- |
- |
| HLA-DRB1*13 |
51 |
15.1 |
54 |
10.4 |
0.0431 |
0.6465 |
1.53 |
1.01-2.31 |
|
ACL (group 1; n = 136) |
|
|
|
|
|
|
|
|
| HLA-DRB1*13 |
44 |
16.2 |
54 |
10.4 |
0.0228 |
0.3420 |
1.66 |
1.08-2.55 |
| HLA-B*35 |
53 |
19.5 |
68 |
13.1 |
0.0218 |
0.6758 |
1.67 |
1.08-2.29 |
| HLA-B*44 |
38 |
14.0 |
46 |
8.9 |
0.0290 |
0.8990 |
1.67 |
1.05-2.64 |
| HLA-B*45 |
0 |
- |
12 |
2.3 |
0.0107 |
0.3317 |
- |
- |
|
ACL (group 1A; n = 118) |
|
|
|
|
|
|
|
|
| HLA-B*44 |
35 |
14.8 |
46 |
8.9 |
0.0160 |
0.4969 |
1.79 |
1.12-2.87 |
| HLA-B*45 |
0 |
- |
12 |
2.3 |
0.0231 |
0.0225 |
- |
- |
| HLA-DRB1*13 |
38 |
16.1 |
54 |
10.4 |
0.0152 |
0.2280 |
1.65 |
1.06-2.59 |
|
ACL (group 2; n = 15) |
|
|
|
|
|
|
|
|
| HLA-B*27 |
3 |
10.0 |
8 |
1.5 |
0.0180 |
0.5580 |
7.11 |
1.78-28.33 |
|
ACL (group 3B; n = 7) |
|
|
|
|
|
|
|
|
| HLA-B*52 |
3 |
21.4 |
11 |
2.1 |
0.0044 |
0.1360 |
12.61 |
3.08-51.66 |
|
ACL (group 4; n = 22) |
|
|
|
|
|
|
|
|
| HLA-B*49 | 4 | 9.1 | 8 | 1.5 | 0.0101 | 0.3131 | 6.4 | 1.8-22.17 |
n = number of times the allele occurs; F = Allele frequency; P-value = calculated by Fisher’s exact test; Pc-value = value of P corrected by Bonferroni correction; OR = odds ratio; 95%CI = 95% confidence interval.