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Microarray analysis also indicated an increase in Wnt signaling and cell cycle regulation in women. (A) Increased turnover of epithelial cells is associated with an increase in expression of genes in the Wnt β Catenin signaling pathway with downstream nuclear effectors such as SOX, HDAC1. (B) A compensatory increase in cell cycle regulation via the G1/S Checkpoint was also observed at the transcriptional level. (Red: Increase in expression, Green: decrease in expression).
