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. 2013 Mar 5;11:22. doi: 10.1186/1741-7007-11-22

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Copyright © 2013 Chen et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Steel factor, Sdf1 and Integrinβ1 expression were unchanged in GR-deficient embryos. The expression patterns of Steel factor, Sdf1 and Integrinβ1 in E10.5 control and Wt1^R394W/R394Wembryos were assessed by immunostaining. Sdf1 was expressed in the urogenital region of both control (A) and Wt1^R394W/R394W(B) embryos. High-magnification images showed that the expression of Sdf1 in the coelomic epithelium (white arrows) was not obviously changed in Wt1^R394W/R394W(D) compared with control embryos (C). Steel factor was detected in the mesentery of control (E) and Wt1^R394W/R394W(F) embryos. G and H are high-magnification images from E and F, respectively. Integrinβ1 was widely expressed in both control (I) and Wt1^R394W/R394W(J) embryos. K and L are high-magnification images of I and G, respectively. da, dorsal artery; gr, genital ridge; hg, hindgut; mes, mesentery. Scale bars: 50 μm. The mRNA level of c-Kit, Steel, Cxcr4, Sdf1, Cdh1 and Integrinβ1 was detected by real-time RT-PCR (M), and normalized against Gapdh. Each bar, mean ± SD of n = 3 experiments.