. Author manuscript; available in PMC: 2013 May 13.

Published in final edited form as: Drug Metab Dispos. 2008 Jul 10;36(10):10.1124/dmd.108.020354. doi: 10.1124/dmd.108.020354

TABLE 1. Pharmacokinetic parameters of bPiDDB.

Mean (± SEM) values for the pharmacokinetic parameters of bPiDDB following s.c. and i.v. administration.

Dose (route)	1 mg/kg (s.c.)	3 mg/kg (s.c.)	5.6 mg/kg (s.c.)	1 mg/kg (i.v.)
Parameter (units)
T_{max (min)}	5.0 ± 0.00	6.7 ± 0.9	8.8 ± 2.3	–
C_max (μg/mL)	0.13 ± 0.01	0.33 ± 0.02^*	0.43 ± 0.04^*	0.33 ± 0.01
t_1/2 (min)	11.2 ± 1.6	19.5 ± 8.3	16.9 ± 1.3	11.9 ± 0.31
AUC^0-∞ (μg.min/mL)	1.59 ± 0.3	4.1 ± 0.9^*	11.5 ± 0.6^*	1.98 ± 0.04
CL (L/h/kg)	0.6 ± 0.1	0.9 ± 0.1	0.7 ± 0.3	0.6 ± 0.03
F (%)	80.3	68.2	103.7	100
V_ss (L/kg)	–	–	–	30 ± 0.7

Values are mean ± SEM; n = 3–5.

p <0.05.