Table 2. Inhibition of inflammation and stress-associated gene expression in CL4176 nematodes.

Gene	Description	Compounds	Average Fold reduction	P value
F22E5.6	TNFA1P1 homolog	galanthamine	2.17		0.039*
		haemanthidine	4.8		0.033*
		1,2-Di-O-acetyllycorine	1.39		0.012*
		1-O-acetyllycorine	1.49		0.152
		memantine	2.78		0.011*
ZC239.12	TNFA1P1 homolog	galanthamine	2.11		0.054
		haemanthidine	0.98		0.079
		1,2-Di-O-acetyllycorine	5.55		0.0066**
		1-O-acetyllycorine	1.41		0.15
		memantine	7.3		0.002**
Y46H3A.D	HSP16-2	galanthamine	1.17		0.0048*
		haemanthidine	1.99		0.007**
		1,2-Di-O-acetyllycorine	0.99		0.002**
		1-O-acetyllycorine	2.06		0.098
		memantine	2.29		0.007**
Y46H3A	HSP16-41	galanthamine	0.94		0.009**
		haemanthidine	2.07		0.025*
		1,2-Di-O-acetyllycorine	0.77		0.008**
		1-O-acetyllycorine	1.81		0.071
		memantine	3.12		0.019*

Average fold-reduction of gene expression was calculated from three independent qRT-PCR analyses by comparing samples from treated and non-treated CL4176 worms collected 26 hr after temperature shift. Student t-test was used to calculate p values for statistical significance,

^* p<0.05,

^** p<0.01.