Table 5.

Validity of HPV testing and in combination with cytology and colposcopy results in predicting outcome of CIN at 12 months (95% CI in parentheses)^*

	6-month
Test condition indicating presence of CIN at 12 months	Sensitivity	Specificity	Positive predictive value	Negative predictive value	AUC
High-risk HPV	45.9 (33.4–58.4)	76.0 (67.8–84.2)	52.8 (39.4–66.3)	70.5 (62.1–79.0)	0.61 (0.53–0.68)
High-risk HPV or cytology ≥ ASC-H	49.2 (36.4–61.9)	68.9 (60.1–77.7)	46.8 (34.4–59.2)	70.9 (62.1–79.7)	0.59 (0.51–0.67)
High-risk HPV or colposcopy +	66.7 (54.4–78.9)	57.3 (47.7–66.8)	46.3 (35.6–57.1)	75.6 (66.1–85.2)	0.62 (0.54–0.70)
High-risk HPV or cytology ≥ ASC-H or colposcopy +	66.7 (54.4–78.9)	53.9 (44.3–63.4)	44.2 (33.7–54.7)	74.7 (64.8–84.5)	0.60 (0.52–0.68)

^*ASC-H: Atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (HSIL). Colposcopy +: Colposcopic impression of CIN based on the appearance of aceto-white foci and/or both punctation and mosaicism on the cervix.