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. Author manuscript; available in PMC: 2013 May 13.
Published in final edited form as: J Cell Physiol. 2011 Aug;226(8):2052–2062. doi: 10.1002/jcp.22543

Figure 6. Rap1 depletion in vivo abolishes protective effects by OxPAPC in the murine model of ventilator induced lung injury.

Figure 6

A and B: Mice were transfected with non-specific or Rap1-specific siRNA (72 hrs) followed by high tidal volume mechanical ventilation (HTV; 30 ml/kg, 4 hrs) with or without OxPAPC treatment. Cell count (A) and protein concentration (B) in BAL samples were analyzed. n=4-6 per condition; *p<0.05. Inset depicts Rap1 depletion in lung samples assessed by western blot. Probing of the membrane with β-actin antibody served as a loading control.