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. 2013 May 1;97(6):1395–1402. doi: 10.3945/ajcn.112.052183

TABLE 1.

Summary of GWA meta-analysis and joint analysis of top loci1

SNP Chr Allele (effect/noneffect) Allele frequency (effect) CHARGE
 DietGen
 CHARGE + DietGen
 CHARGE + DietGen (BMI adjusted)
β ± SE P value β ± SE P value β ± SE P value β ± SE P value
Carbohydrate
 rs1667320 2 G/T 0.49 (0.01) −0.31 ± 0.06 1.25 × 10−7 0.02 ± 0.06 0.8147 −0.16 ± 0.04 0.0002 −0.14 ± 0.04 0.0012
 rs2840445 8 A/G 0.27 (0.02) −0.32 ± 0.06 7.55 × 10−7 −0.10 ± 0.07 0.1781 −0.22 ± 0.05 4.52 × 10−6 −0.20 ± 0.05 5.78 × 10−5
 rs12122737 1 A/C 0.20 (0.02) 0.35 ± 0.07 1.64 × 10−6 −0.14 ± 0.08 0.0871 0.13 ± 0.05 0.0148 0.12 ± 0.05 0.0247
 rs12356048 10 G/A 0.32 (0.02) 0.30 ± 0.06 2.44 × 10−6 −0.10 ± 0.07 0.1669 0.12 ± 0.05 0.0108 0.08 ± 0.05 0.1034
 rs12912584 15 A/G 0.25 (0.02) 0.31 ± 0.07 3.99 × 10−6 −0.10 ± 0.07 0.1814 0.13 ± 0.05 0.0117 0.10 ± 0.05 0.0353
 rs1542608 7 G/A 0.18 (0.02) 0.37 ± 0.08 4.23 × 10−6 0.00 ± 0.08 0.9857 0.19 ± 0.06 0.0008 0.17 ± 0.06 0.0035
 rs10508303 10 A/C 0.07 (0.02) 0.60 ± 0.13 4.82 × 10−6 −0.18 ± 0.13 0.1644 0.20 ± 0.09 0.0270 0.19 ± 0.09 0.0328
 rs1893113 6 T/C 0.50 (0.01) 0.27 ± 0.06 5.19 × 10−6 −0.01 ± 0.06 0.8810 0.14 ± 0.04 0.0011 0.12 ± 0.04 0.0045
 rs8019546 14 A/G 0.30 (0.01) 0.29 ± 0.06 5.93 × 10−6 0.13 ± 0.07 0.0750 0.22 ± 0.05 5.01 × 10−6 0.19 ± 0.05 5.14 × 10−5
 rs838145 19 G/A 0.46 (0.04) 0.27 ± 0.06 6.21 × 10−6 0.17 ± 0.07 0.0083 0.23 ± 0.04 3.13 × 10−7 0.25 ± 0.04 1.68 × 10−8
 rs1549309 5 A/G 0.17 (0.02) 0.34 ± 0.07 9.50 × 10−6 0.18 ± 0.08 0.0350 0.27 ± 0.06 2.47 × 10−6 0.25 ± 0.06 1.59 × 10−5
Protein
 rs1350036 4 T/C 0.48 (0.03) −0.14 ± 0.02 1.72 × 10−8 −0.01 ± 0.02 0.7601 −0.07 ± 0.02 3.49 × 10−5 −0.07 ± 0.02 2.19 × 10−5
 rs1421085 16 C/T 0.42 (0.02) 0.12 ± 0.03 1.53 × 10−6 0.10 ± 0.03 0.0002 0.11 ± 0.022 1.65 × 10−9 0.09 ± 0.023 4.80 × 10−7
 rs1191005 14 T/C 0.12 (0.01) 0.19 ± 0.04 1.59 × 10−6 −0.02 ± 0.04 0.5944 0.08 ± 0.03 0.0042 0.08 ± 0.03 0.0042
 rs9553939 13 G/A 0.43 (0.02) −0.12 ± 0.03 3.60 × 10−6 −0.02 ± 0.03 0.4968 −0.07 ± 0.02 0.0002 −0.07 ± 0.02 0.0003
 rs11640535 16 A/G 0.27 (0.03) 0.14 ± 0.03 3.72 × 10−6 0.00 ± 0.03 0.8746 0.06 ± 0.02 0.0019 0.07 ± 0.02 0.0002
 rs16993715 21 T/C 0.04 (0.01) 0.32 ± 0.07 8.17 × 10−6 0.05 ± 0.07 0.4621 0.18 ± 0.05 0.0003 0.17 ± 0.05 0.0007
 rs11699457 20 A/G 0.19 (0.01) 0.14 ± 0.03 9.08 × 10−6 0.03 ± 0.03 0.3966 0.08 ± 0.02 0.0002 0.08 ± 0.02 0.0003
 rs7086704 10 G/T 0.25 (0.02) −0.13 ± 0.03 9.61 × 10−6 −0.01 ± 0.03 0.6798 −0.07 ± 0.02 0.0008 −0.05 ± 0.02 0.0091
Fat
 rs7625360 3 C/A 0.24 (0.01) 0.30 ± 0.06 1.77 × 10−7 0.02 ± 0.06 0.7715 0.16 ± 0.04 9.78 × 10−5 0.14 ± 0.04 0.0006
 rs838145 19 G/A 0.46 (0.04) −0.25 ± 0.05 3.43 × 10−7 −0.19 ± 0.05 0.0002 −0.22 ± 0.04 4.48 × 10−10 −0.21 ± 0.04 1.57 × 10−9
 rs2609186 2 A/G 0.31 (0.05) −0.25 ± 0.05 9.93 × 10−7 −0.01 ± 0.05 0.8458 −0.14 ± 0.04 0.0002 −0.13 ± 0.04 0.0007
 rs7997717 13 A/G 0.05 (0.01) −0.55 ± 0.11 2.99 × 10−6 0.03 ± 0.12 0.8167 −0.27 ± 0.08 0.0014 −0.28 ± 0.08 0.0009
 rs12156272 8 C/A 0.17 (0.01) −0.28 ± 0.06 5.59 × 10−6 −0.02 ± 0.06 0.7255 −0.16 ± 0.04 0.0004 −0.16 ± 0.04 0.0003
 rs3114727 7 A/G 0.40 (0.01) 0.22 ± 0.05 5.76 × 10−6 0.03 ± 0.05 0.5503 0.13 ± 0.03 0.0002 0.13 ± 0.03 0.0001
 rs11725988 4 G/A 0.26 (0.02) 0.26 ± 0.06 6.80 × 10−6 0.02 ± 0.06 0.7473 0.14 ± 0.04 0.0006 0.14 ± 0.04 0.0007
 rs4683038 3 T/G 0.27 (0.02) 0.25 ± 0.05 7.78 × 10−6 −0.02 ± 0.06 0.7704 0.12 ± 0.04 0.0026 0.11 ± 0.04 0.0052
 rs10152629 15 A/G 0.02 (0.01) 0.80 ± 0.18 8.47 × 10−6 −0.12 ± 0.19 0.5250 0.37 ± 0.13 0.0045 0.36 ± 0.13 0.0066
1

All analyses were adjusted for age, sex and study sex and study-specific covariates (eg, study site, population stratification principal components when applicable) (P < 10−6). CHARGE, Cohorts for Heart and Aging Research in Genomic Epidemiology; Chr, chromosome; GWA, genome-wide association; SNP, single nucleotide polymorphism.

2,3

Meta-analysis with 3 cohorts with Illumina MetaboChip data (n = 7724): 2β ± SE = 0.10 ± 0.02%, P = 9.96 × 10−10; 3β ± SE = 0.08 ± 0.02%, P = 3.15 × 10−7.