Schematic shows current targeted cancer therapies approved by the Food and Drug Administration and their interactions with their primary molecular targets. EGFR = epidermal growth factor receptor, ErbB2 (formerly, HER2) = human epidermal growth factor, VEGF = vascular endothelial growth factor, VEGFR = VEGF receptor, KIT = stem cell factor receptor, ALK-FP = anaplastic lymphoma kinase fusion protein.