Fig. 9.

Qualitative explanation of how chemical synapses can differentially influence cycle frequency based on network phasing. Green portions of the traces mark periods where the postsynaptic current is active and acting to hyperpolarize membrane potential. Red portions of the traces mark periods where the postsynaptic current is active and acting to depolarize membrane potential. Black dotted lines mark burst threshold (0 mV). Magenta dotted lines mark the synaptic reversal potential (−15 mV). Scale bars = 500 ms and 30 mV. A: network with similar duty cycles, in which cycle frequency decreased after chemical synapses were removed. Model parameters were as follows: top oscillator (g_Ca, 46.8; g_K, 48.4; g_L, 3.07; and g_syn, 37.28), bottom oscillator (g_Ca, 27.7; g_K, 30.6; g_L, 6.72; and g_syn, 14.7), and electrical coupling (g_gap, 35.2). B: network with disparate duty cycles, in which cycle frequency increased after chemical synapses were removed. Model parameters were as follows: top oscillator (g_Ca, 77.6; g_K, 73.9; g_L, 8.74; and g_syn, 25.9), bottom oscillator (g_Ca, 69.6; g_K, 91.5; g_L, 9.68; and g_syn, 1.94), and electrical coupling (g_gap, 35.2).