Fig. 2.

Effects of the general muscarinic glutamate receptor (mGluR) agonist 1-aminocyclopentane-1,3-dicarboxylic acid (ACPD) on the synaptic properties of Class 1 inputs to layer 4 cells in V1 activated from the white matter. A: example from 1 cell showing effects of ACPD on synaptic responses. B: graph showing population data in the form of normalized amplitudes of the first EPSC before, during, and after ACPD application. The EPSC amplitude (mean ± SE) was significantly decreased by ACPD (P < 0.001, repeated-measures ANOVA). C: graph showing that ACPD application greatly increased PPR (mean ± SE, see Fig. 1; *P < 0.05, repeated-measures ANOVA, for ISI = 15 and 40 ms). With ACPD, such depression was abolished at all intervals (P > 0.1, on a repeated measure ANOVA).