Figure 2. MPTP causes axonal transport impairment.

(a) Mask projections of sagittal sections of the nigrostriatal pathway in mice injected with saline or MPTP as in Fig. 1, showing the distribution of mitochondria (white spots) inside dopaminergic fibres (red). Arrowheads indicate mitochondria accumulations and arrow highlights an empty fibre. Scale bar = 20 μm. (b) Percentage of fibres displaying a homogeneous distribution of mitochondria, fibres showing dispersed or accumulated mitochondria or empty fibres. hpi = hours post last injection of MPTP (mean ± S.E.M., n = 9 sections from 3 different mice per group). *P < 0.05; χ² test versus saline-injected mice.