Odds ratios/copy of 9p21 risk allele for MI in subjects with CAD (allelic model), stratified according to CAD definition (clinical, angiographic stenosis ≥50% or ≥70%). Total n = 33,673; 17,791 CAD+/MI+, 15,882 CAD+/MI−. ADVANCE = Atherosclerotic Disease, Vascular Function, and Genetic Epidemiology; CAD/MI+ = cases with history of MI and underlying CAD; CAD/M− = control subjects without history of MI but with underlying CAD; LCAS = Lipoprotein and Coronary Atherosclerosis Study; PROCARDIS = Precocious Coronary Artery Disease; WTCCC = Wellcome Trust Case-Control Consortium; other abbreviations as in Figures 1, 2, and 3.