Table 1.
Description of Studies Included in Meta-Analysis
| First Author (Ref. #) | Cohort | Country | SNP (effect allele) |
Risk Allele Frequency |
Mean or Cutoff Age (yrs) | Ethnicity | Male% | Coronary Angiography | No. of Subjects | CAD Definitions | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1-Vessel Disease |
2-Vessel Disease |
3-Vessel Disease |
CAD/MI+ (nondiabetic subjects) |
CAD/MI− (nondiabetic subjects) |
CAD Definition | ||||||||
| Assimes et al. (11) | ADVANCE | U.S. | rs10757278 (G) | 0.53 | Mean age 58.2. Early onset CAD were 18 to 45 yrs (men) and 18 to 55 women, older onset were any age >18 but also not eligible to be included in early onset group | European ancestry/African/East Asian/South Asian | 67.7% | — | — | — | 1,005 (809) | 547 (432) | Clinical/symptomatic |
| Broadbent et al. (23)* | PROCARDIS | Germany, Italy, Sweden, and U.K. | rs1333049 (C) | 0.52 | Mean age (at date of recruitment) 62.2 yrs | European ancestry | 72.7% | — | — | — | 2,890 (2449) | 1361 (1158) | Clinical/symptomatic |
| Chen et al. (15) | LCAS | U.S. | rs1333049 (C) | 0.55 | Mean age 59.3±7.7, all <75 yrs | European ancestry | 84.0% | — | — | — | 141 | 191 | Angiography (30%–75% stenosis) |
| Dandona et al. (12) | OHGS (Early onset) | U.S. | rs1333049 (C) | 0.55 | Mean age 56.1±9.6, male <55 yrs and female <65 yrs | European ancestry | 70.8% | 518 | 563 | 633 | 517 (517) | 433 (433) | Angiography (≥50% stenosis) |
| OHGS (Late onset) | U.S. | rs1333049 (C) | 0.55 | Mean age 70.0±8.0 | European ancestry | 82.6% | — | — | — | 271 (271) | 493 (493) | Angiography (≥50% stenosis) | |
| Ellis et al. (9) | CDCS | New Zealand | rs1333049 (C) | 0.51 | Mean age 67.1±12.5 | European ancestry/Asian/ Pacific Island ancestry | 69.2% | 201 | 205 | 272 | 854 (703) | 162 (142) | Angiography (≥50% stenosis) |
| Gong et al. (25) | INVEST | U.S. | rs1333049 (C) | 0.54 | Mean age 66±10 | European ancestry/African/Hispanic | 44.2% | — | — | — | 443 (344) | 997 (713) | Clinical/symptomatic |
| Hauser et al. | CATHGEN | U.S. | rs10757278 (G) | 0.52 | Mean age 64.4±11.0 (CAD/MI+ group), 61.02±10.65 (CAD/MI− group) | European ancestry | 73.0% | 1,049 | 792 | 1180 | 1,357 (941) | 1664 (1,159) | Angiography (≥50% stenosis) |
| Hazen et al. | Cleveland GB | USA | rs1333049 (C) | 0.54 | Mean age 61.7.9±11.1 | European ancestry | 74.0% | 745 | 672 | 1,054 | 1,332 (1039) | 1079 (806) | Angiography (≥50% stenosis) |
| Hinohara et al. (36) | — | Japan | rs1333049 (C) | 0.56 | Mean age 59.3±10.1 | Japanese | 83.3% | 245 | 170 | 181 | 572 (395) | 47 (29) | Angiography (≥50% stenosis) |
| Hinohara et al. (36) | — | Korea | rs1333049 (C) | 0.52 | Mean age 61.2±11.1 | Korean | 76.4% | 243 | 162 | 117 | 433 (222) | 260 (51) | Angiography (≥50% stenosis) |
| Hoppmann et al. (37) | — | Germany | rs1333049 (C) | 0.51 | Mean age 66.3±10.5 | European ancestry | 78.2% | 364 | 579 | 1,085 | 733 | 1295 | Angiography (≥50% stenosis) |
| Horne et al. (7) | IHCS (Sample set) | U.S. | rs2383206 (C) | 0.54 | Mean age 63±10 yrs (range 21–78 yrs) | European ancestry | 77.0% | 666 | 473 | 609 | 869 (613) | 879 (705) | Angiography (≥70% stenosis) |
| IHCS (Replication set) | U.S. | rs2383206 (C) | 0.53 | Mean age 61±10 yrs (range 24–75 yrs) | European ancestry | 73.0% | 429 | 300 | 285 | 507 (347) | 507 (368) | Angiography (≥70% stenosis) | |
| Krawczak et al. (38) | PopGen | Germany | rs1333049 (C) | 0.51 | Mean age 47.6±6.3 | European ancestry | 79.4% | — | — | — | 1,366 (1,111) | 718 (584) | Angiography (≥70% stenosis) |
| Muendlein et al. (39) | — | Austria | rs1333049 (C) | 0.55 | Mean age 65.1± 10.6; male 64.1 ± 10.8; female 68.6 ± 9.2 | European ancestry | 77.1% | 362 | 290 | 262 | 357 (248) | 576 (429) | Angiography (≥50% stenosis) |
| Patel et al. (13) | EmCB | U.S. | rs10757278 (G) | 0.51 | Mean age 63.9±11 | European ancestry | 67.8% | 498 | 545 | 1,314 | 891 (611) | 864 (596) | Angiography (≥50% stenosis) |
| Reilly et al. (8) | MEDSTAR | U.S. | rs1333049 (C) | 0.54 | All aged <61, male <55 and female <60 | European ancestry | 71.9% | 330 | 290 | 204 | 421 (294) | 454 (308) | Angiography (≥50% stenosis) |
| Reilly et al. (8) | PENNCATH | U.S. | rs1333049 (C) | 0.57 | All aged <66, male <60 and female <65 | European ancestry | 75.0% | 247 | 258 | 336 | 470 (123) | 463 (111) | Angiography (≥50% stenosis) |
| Samani et al. (1) | WTCCC | U.K. | rs1333049 (C) | 0.55 | All Aged <66 | European ancestry | 79.5% | — | — | — | 1,376 (1214) | 532 (467) | Clinical/symptomatic |
| Shen et al. (40) | SK-CAD | Korea | rs10757278 (G) | 0.53 | Mean age 63.7±10.1 | Korean | 70.9% | — | — | — | 603 (410) | 485 (332) | Angiography (≥70% stenosis) |
| Wang et al. (41) | — | China | rs1333049 (C) | 0.54 | Mean age 66.81±9.8 | Chinese | 56.1% | 419 | 389 | 357 | 555 (300) | 610 (245) | Angiography (≥50% stenosis) |
| Ye et al. (42) | SAS | U.K. | rs1333049 (C) | 0.52 | Mean age 63.2±9.95 | European ancestry | 76.6% | 439 | 373 | 282 | 592 (513) | 501 (434) | Angiography (≥50% stenosis) |
*
Allele frequencies were estimated from computed odds ratio.
CDCS = Coronary Disease Cohort Study; Cleveland GB = Cleveland GeneBank Study; EmCB = Emory Cardiovascular Biobank; IHCS = Utah Intermountain Heart Collaborative Study; LCAS = Lipoprotein and Coronary Atherosclerosis Study; INVEST = International Verapamil SR Trandolapril Study Genetic Substudy; OHGS = Ottawa Heart Genomics Study; PROCARDIS = Precocious Coronary Artery Disease; SAS = Southampton Atherosclerosis Study; WTCCC = Wellcome Trust Case-Control Consortium.