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Average age trajectories (±s.e.) of total cholesterol (“CH”) for female and male carriers (“e4”) and noncarriers (“no e4”) of the APOE e4 allele who survived until different ages (“LS” denotes life span); f(t, G) are age trajectories for the long-lived groups fitted by cubic polynomials (used as physiological “norms” in the genetic stochastic process model, see the text). Data source: Framingham Heart Study (original cohort).
