Table 2.

Results from WLE and AFV with corresponding histopathologic diagnosis for 249 individual sites that were biopsied for this surveillance study

Pathology diagnosis	WLE		AFV			WLE + AFV			Total
	Nonsuspicious	Suspicious	Nonsuspicious	Suspicious	P*	Nonsuspicious	Suspicious†	P‡
Benign
Normal	19	4	11	12		9	14		23
Simple hyperplasia	1	3	3	1		1	3		4
Parakeratosis	22	8	17	13		15	15		30
Parakeratosis with hyperplasia	13	9	8	14		5	17		22
Total	55	24	39	40	0.02	30	49	<0.001	79
Low-grade lesions
Parakeratosis with atypia	33	23	23	33		17	39		56
Mild dysplasia	35	30	22	43		13	52		65
Total	68	53	45	76	0.004	30	91	<0.001	121
High-grade lesions
Moderate dysplasia	5	13	1	17		—	18		18
Severe dysplasia	—	6	—	6		—	6		6
CIS OR microinvasive SCC	5	5	—	10		—	10		10
Total	10	24	1	33	0.006	0	34	0.006	34
Cancers
Invasive SCC	2	10	1	11		—	12		12
Other carcinoma§	1	2	—	3		—	3		3
Total	3	12	1	14	0.59	0	15	0.22	15
Total	136	113	86	163		60	189		249

^*P value for WLE findings compared with AFV calculated by two-tailed Fisher’s exact test.

^†Suspicious on either WLE or AFV.

^‡P value for WLE findings compared with (WLE + AFV) calculated by two-tailed Fisher’s exact test.

^§Includes one adenocarcinoma (salivary gland carcinoma) and two verrucous carcinomas with SCC component.