Table 2.
Associations between BMP-related genes and risk of breast cancer overall and by ER/PR status
| Overall | ER + PR +1 | ER + PR − | ER − PR + | ER − PR − | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Controls | Cases | (N=1292 cases) | (N=235 cases) | (N=41 cases) | (N=411 cases) | |||||||
| N | N | OR2 | (95% CI) | OR | (95% CI) | OR | (95% CI) | OR | (95% CI) | OR | (95% CI) | |
| ACVR1 (rs2033962) | ||||||||||||
| GG | 2940 | 2452 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| GT/TT | 1159 | 1081 | 1.09 | (0.99, 1.20) | 1.27 | (1.11, 1.46) | 0.96 | (0.71, 1.29) | 0.94 | (0.46, 1.90) | 1.13 | (0.91, 1.42) |
| ACVR1 (rs4380178) | ||||||||||||
| GG | 3046 | 2538 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| GA/AA | 1053 | 997 | 1.12 | (1.01, 1.24) | 1.25 | (1.08, 1.44) | 0.96 | (0.71, 1.30) | 1.01 | (0.50, 2.04) | 1.25 | (1.00, 1.57) |
| ACVR1 (rs920522) | ||||||||||||
| TT | 3501 | 2970 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| TC/CC | 601 | 565 | 1.13 | (1.00, 1.28) | 1.33 | (1.12, 1.59) | 1.43 | (1.01, 2.03) | 0.79 | (0.31, 2.04) | 0.94 | (0.70, 1.27) |
| ACVR1 (rs17182166) | ||||||||||||
| GG/GT | 4051 | 3466 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| TT | 51 | 68 | 1.40 | (0.97, 2.03) | 1.47 | (0.93, 2.33) | 1.27 | (0.49, 3.24) | 1.66 | (0.22, 12.62) | 2.12 | (1.13, 3.97) |
| ACVR1 (rs1146035) | ||||||||||||
| GG | 2958 | 2467 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| GT/TT | 1144 | 1066 | 1.08 | (0.98, 1.20) | 1.26 | (1.10, 1.45) | 0.97 | (0.72, 1.30) | 1.02 | (0.52, 2.03) | 1.10 | (0.88, 1.38) |
| ACVR1 (rs10497191) | ||||||||||||
| CC | 3050 | 2578 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CT/TT | 1050 | 957 | 1.09 | (0.98, 1.21) | 1.20 | (1.04, 1.39) | 1.23 | (0.92, 1.66) | 0.92 | (0.45, 1.89) | 1.06 | (0.84, 1.33) |
| ACVR1 (rs10497192) | ||||||||||||
| TT | 2206 | 1852 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| TC | 1606 | 1409 | 1.04 | (0.95, 1.15) | 1.20 | (1.05, 1.38) | 1.01 | (0.76, 1.34) | 0.86 | (0.45, 1.66) | 1.08 | (0.87, 1.34) |
| CC | 290 | 274 | 1.13 | (0.94, 1.35) | 1.39 | (1.09, 1.77) | 1.13 | (0.68, 1.87) | 0.84 | (0.25, 2.85) | 1.02 | (0.68, 1.53) |
| ACVR1 (rs4233672) | ||||||||||||
| GG | 2764 | 2303 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| GA/AA | 1337 | 1231 | 1.10 | (1.00, 1.21) | 1.22 | (1.07, 1.40) | 0.99 | (0.75, 1.32) | 0.95 | (0.48, 1.85) | 1.14 | (0.92, 1.41) |
| ACVR1 (rs10933443) | ||||||||||||
| TT | 2341 | 1994 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| TC/CC | 1756 | 1538 | 1.02 | (0.93, 1.12) | 1.19 | (1.04, 1.35) | 1.00 | (0.76, 1.31) | 1.21 | (0.65, 2.26) | 1.07 | (0.87, 1.32) |
| ACVR1 (rs2883605) | ||||||||||||
| GG | 3568 | 3047 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| GT/TT | 483 | 438 | 1.00 | (0.87, 1.15) | 1.06 | (0.87, 1.28) | 0.59 | (0.37, 0.95) | 0.95 | (0.37, 2.48) | 1.11 | (0.82, 1.49) |
| ACVR1 (rs10497193) | ||||||||||||
| AA/AG | 4002 | 3447 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| GG | 99 | 87 | 1.04 | (0.77, 1.39) | 1.01 | (0.66, 1.53) | 2.07 | (1.08, 3.98) | 1.76 | (0.41, 7.51) | 0.80 | (0.40, 1.61) |
| ACVR1 (rs4664901) | ||||||||||||
| TT/TC | 3891 | 3338 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CC | 207 | 195 | 1.10 | (0.90, 1.35) | 1.11 | (0.84, 1.48) | 1.94 | (1.21, 3.11) | 1.31 | (0.40, 4.32) | 1.01 | (0.64, 1.58) |
| ACVRL1 (rs11169953) | ||||||||||||
| CC | 2003 | 1787 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CT/TT | 2098 | 1747 | 0.91 | (0.83, 1.00) | 0.93 | (0.81, 1.06) | 1.05 | (0.80, 1.37) | 1.31 | (0.70, 2.46) | 0.73 | (0.60, 0.90) |
| BMP4 (rs17563) | ||||||||||||
| TT | 1449 | 1056 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| TC/CC | 2376 | 2159 | 1.16 | (1.05, 1.29) | 1.29 | (1.10, 1.51) | 1.26 | (0.90, 1.77) | 1.39 | (0.64, 3.02) | 1.38 | (1.06, 1.80) |
| BMP4 (rs762642) | ||||||||||||
| TT/TG | 3391 | 2957 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| GG | 710 | 578 | 0.93 | (0.82, 1.05) | 0.96 | (0.80, 1.14) | 0.62 | (0.40, 0.94) | 1.26 | (0.58, 2.77) | 0.90 | (0.68, 1.20) |
| BMP4 (rs2761887) | ||||||||||||
| AA | 1295 | 1067 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AC/CC | 2805 | 2466 | 1.07 | (0.97, 1.18) | 1.10 | (0.95, 1.27) | 1.54 | (1.13, 2.11) | 1.10 | (0.55, 2.16) | 1.19 | (0.95, 1.50) |
| BMP4 (rs4898820) | ||||||||||||
| TT/TG | 3147 | 2743 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| GG | 955 | 790 | 0.95 | (0.85, 1.06) | 0.95 | (0.81, 1.11) | 0.62 | (0.43, 0.90) | 1.00 | (0.47, 2.11) | 0.95 | (0.74, 1.22) |
| BMPR2 (rs12621870) | ||||||||||||
| TT | 2525 | 2171 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| TC | 1354 | 1178 | 1.00 | (0.91, 1.10) | 1.04 | (0.91, 1.20) | 0.94 | (0.70, 1.25) | 1.93 | (0.98, 3.77) | 0.90 | (0.72, 1.13) |
| CC | 212 | 174 | 0.94 | (0.76, 1.17) | 1.06 | (0.79, 1.42) | 1.24 | (0.71, 2.16) | 4.20 | (1.62, 10.91) | 0.76 | (0.45, 1.28) |
| GDF10 (rs7093975) | ||||||||||||
| CC | 2346 | 2001 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CT | 1526 | 1285 | 0.97 | (0.88, 1.06) | 0.93 | (0.81, 1.06) | 0.90 | (0.67, 1.20) | 1.61 | (0.82, 3.15) | 0.96 | (0.77, 1.20) |
| TT | 229 | 244 | 1.22 | (1.01, 1.48) | 1.19 | (0.91, 1.56) | 1.42 | (0.86, 2.33) | 3.62 | (1.40, 9.41) | 1.24 | (0.82, 1.89) |
| GDF10 (rs762454) | ||||||||||||
| AA | 2228 | 1802 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AG | 1553 | 1432 | 1.12 | (1.02, 1.23) | 1.13 | (0.99, 1.30) | 1.26 | (0.95, 1.68) | 0.65 | (0.32, 1.31) | 1.02 | (0.82, 1.26) |
| GG | 312 | 293 | 1.09 | (0.92, 1.30) | 1.07 | (0.84, 1.36) | 1.77 | (1.15, 2.71) | 1.31 | (0.49, 3.50) | 0.53 | (0.33, 0.87) |
| GDF10 (rs2853838) | ||||||||||||
| CC | 2554 | 2197 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CA | 1379 | 1182 | 1.00 | (0.90, 1.10) | 0.97 | (0.84, 1.12) | 0.94 | (0.71, 1.26) | 2.04 | (1.06, 3.91) | 1.03 | (0.82, 1.28) |
| AA | 169 | 155 | 1.09 | (0.87, 1.36) | 1.07 | (0.77, 1.48) | 1.24 | (0.67, 2.30) | 3.85 | (1.27, 11.71) | 1.33 | (0.82, 2.15) |
1
Estrogen Receptor (ER) and Progesterone Receptor (PR) data were compared to 3125 controls from sites where cases have ER/PR data
2
Odds Ratios (OR) and 95% Confidence Intervals (CI) adjusted for age, study, BMI in referent year, vigorous activity in referent year, parity, age at first birth, alcohol consumption and genetic admixture; bold text designates significant associations at the 0.05 level after adjustment for multiple comparisons