Table 3.
Associations between candidate genes and breast cancer by genetic admixture
| 0 - 28% Native American Ancestry | 29 - 70% Native American Ancestry | 71 -100% Native American Ancestry | Interaction | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| Controls | Cases | Controls | Cases | Controls | Cases | Raw | Holms | |||||||
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| N | N | OR1,2 | (95% CI) | N | N | OR | (95% CI) | N | N | OR | (95% CI) | P-value | P-value | |
| ACVR2A (rs1014064) | ||||||||||||||
| AA | 848 | 837 | 1.00 | 552 | 435 | 1.00 | 141 | 129 | 1.00 | 0.20 | 0.39 | |||
| AG/GG | 971 | 897 | 0.93 | (0.82, 1.06) | 1109 | 935 | 1.08 | (0.92, 1.26) | 481 | 302 | 0.69 | (0.51, 0.92) | ||
| ACVR2A (rs2161983) | ||||||||||||||
| CC | 835 | 822 | 1.00 | 545 | 432 | 1.00 | 138 | 129 | 1.00 | 0.13 | 0.39 | |||
| CT/TT | 983 | 911 | 0.94 | (0.82, 1.07) | 1116 | 938 | 1.07 | (0.92, 1.25) | 484 | 302 | 0.67 | (0.50, 0.90) | ||
| ACVR2A (rs3768687) | ||||||||||||||
| GG | 847 | 834 | 1.00 | 550 | 435 | 1.00 | 140 | 129 | 1.00 | 0.16 | 0.39 | |||
| GA/AA | 968 | 896 | 0.94 | (0.82, 1.07) | 1109 | 931 | 1.07 | (0.91, 1.25) | 480 | 302 | 0.68 | (0.51, 0.92) | ||
| ACVR2A (rs10497025) | ||||||||||||||
| CC | 1024 | 1013 | 1.00 | 1097 | 837 | 1.00 | 400 | 300 | 1.00 | 0.60 | 0.60 | |||
| CG/GG | 795 | 720 | 0.92 | (0.80, 1.05) | 564 | 533 | 1.23 | (1.05, 1.43) | 222 | 131 | 0.75 | (0.57, 0.99) | ||
| ACVR2B (rs928813) | ||||||||||||||
| GG | 359 | 353 | 1.00 | 685 | 531 | 1.00 | 360 | 217 | 1.00 | 0.005 | 0.01 | |||
| GT/TT | 1454 | 1369 | 0.97 | (0.82, 1.15) | 973 | 834 | 1.11 | (0.95, 1.29) | 262 | 210 | 1.35 | (1.04, 1.76) | ||
| ACVR2B (rs2276541) | ||||||||||||||
| AA | 672 | 600 | 1.00 | 452 | 371 | 1.00 | 139 | 119 | 1.00 | 0.02 | 0.03 | |||
| AG/GG | 1147 | 1132 | 1.10 | (0.95, 1.26) | 1209 | 999 | 1.01 | (0.86, 1.20) | 483 | 312 | 0.69 | (0.51, 0.93) | ||
| BMP4 (rs17563) | ||||||||||||||
| TT | 396 | 316 | 1.00 | 692 | 500 | 1.00 | 361 | 240 | 1.00 | 0.82 | 1.00 | |||
| TC/CC | 1365 | 1330 | 1.24 | (1.05, 1.47) | 785 | 660 | 1.16 | (0.99, 1.36) | 226 | 169 | 1.13 | (0.86, 1.49) | ||
| BMP4 (rs762642) | ||||||||||||||
| TT | 635 | 587 | 1.00 | 550 | 495 | 1.00 | 226 | 147 | 1.00 | 0.659 | 1.00 | |||
| TG | 878 | 857 | 1.05 | (0.91, 1.22) | 814 | 665 | 0.89 | (0.76, 1.05) | 288 | 206 | 1.09 | (0.81, 1.45) | ||
| GG | 305 | 290 | 1.01 | (0.83, 1.24) | 297 | 210 | 0.77 | (0.62, 0.96) | 108 | 78 | 1.08 | (0.74, 1.57) | ||
| BMP4 (rs2761887) | ||||||||||||||
| AA/AC | 1468 | 1399 | 1.00 | 1373 | 1088 | 1.00 | 480 | 345 | 1.00 | 0.91 | 1.00 | |||
| CC | 350 | 334 | 1.01 | (0.86, 1.20) | 287 | 281 | 1.27 | (1.05, 1.53) | 142 | 86 | 0.85 | (0.62, 1.16) | ||
| BMP7 (rs7273197) | ||||||||||||||
| CC | 839 | 792 | 1.00 | 949 | 854 | 1.00 | 381 | 269 | 1.00 | 0.26 | 0.84 | |||
| CT/TT | 980 | 942 | 1.02 | (0.90, 1.17) | 712 | 516 | 0.79 | (0.68, 0.92) | 241 | 162 | 0.88 | (0.67, 1.15) | ||
| BMPR2 (rs17199235) | ||||||||||||||
| AA | 1426 | 1348 | 1.00 | 1441 | 1236 | 1.00 | 598 | 413 | 1.00 | 0.12 | 0.73 | |||
| AG/GG | 393 | 386 | 1.03 | (0.88, 1.21) | 220 | 134 | 0.67 | (0.53, 0.84) | 24 | 18 | 0.93 | (0.48, 1.81) | ||
1
Bold indicates adjusted odds ratio (OR) estimates remained significant at ≤0.05 after adjustment for multiple comparisons.
2
Odds Ratios (OR) and 95% Confidence Intervals (CI ) adjusted for age, study, genetic admixture, BMI in referent year, vigorous activity in referent year, parity, age at first birth and alcohol consumption.