Figure 1.

A-F, Lum^−/− mice showed reduced lung stretch-induced microvascular leak, lung edema, neutrophil sequestration, oxygen radicals, and TGF-β1 and MIP-2 production. EBD analysis (A), lung wet weight-to-dry-weight ratio (B), MPO assay (C), MDA assay (D), and MIP-2 (E) and TGF-β1 (F) production in BAL fluid were from nonventilated control mice and mice ventilated at Vt 6 mL/kg or 30 mL/kg for 8 h with room air (n = 5 per group). *P < .05 vs nonventilated control mice; †P < .05 vs all other groups. EBD = Evans blue dye; lum^−/− = lumican null; MDA = malondialdehyde; MIP-2 = macrophage inflammatory protein-2; MPO = myeloperoxidase; OD = optical density; TGF-β1 = transforming growth factor-β1; WT = wild type; Vt = tidal volume.