Table 2.

—Physiologic Conditions at the Beginning and End of Ventilation

Condition	Control Nonventilated Wild Type	Control Nonventilated Lum−/−	Vt 6 mL/kg Wild Type	Vt 10 mL/kg Wild Type	Vt 30 mL/kg Wild Type	Vt 30 mL/kg PD98059	Vt 30 mL/kg Lum−/−
pH	7.42 ± 0.03	7.40 ± 0.05	7.36 ± 0.05	7.36 ± 0.07	7.35 ± 0.06	7.34 ± 0.09	7.36 ± 0.04
Pao2, mm Hg	96.1 ± 0.2	96.8 ± 0.1	92.7 ± 1.2	90.1 ± 1.3	85.1 ± 1.4	91.2 ± 1.5	91.8 ± 1
Pao2/Fio2 ratio	457.6 ± 9.2	461 ± 9.1	441.4 ± 7.1	429.1 ± 6.8	405.2 ± 7.4a	434.3 ± 6.6	437.1 ± 7.9
Paco2, mm Hg	39.1 ± 0.1	38.9 ± 0.1	41.3 ± 0.6	38.3 ± 0.7	35.1 ± 1.2	35.4 ± 1.6	35.6 ± 1.3
MAP, mm Hg
Start	84 ± 1.1	83 ± 0.9	83.2 ±± 1.2	83.1 ± 1.4	82.8 ± 1.6	82.6 ± 1.5	82.5 ± 1.3
End	83 ± 0.5	82 ± 0.4	80.4 ± 1.7	79.6 ± 2.1	76.6 ± 5.2	77.1 ± 4.8	77.9 ± 2.8
PIP, mm Hg
Start	…	…	9.7 ± 1.2	15.2 ± 1.3	23.4 ± 1.5	23.5 ± 1.7	23.2 ± 1.4
End	…	…	11.2 ± 0.8	16.7 ± 1.6	27.9 ± 2.4	26.2 ± 3.1	25.9 ± 2.1

Data are presented as mean ± SD. Arterial blood gas levels and mean arterial pressure were obtained from nonventilated control mice and mice ventilated at a Vt of 6 mL/kg, 10 mL/kg, or 30 mL/kg for 8 h (n = 10 per group). MAP = mean arterial pressure; PIP = peak inspiratory pressure. See Table 1 legend for expansion of other abbreviations.

^aP < .05 vs all other groups. The physiologic data of the control groups were similar during the experiment and were used as the beginning data of ventilation.