Table 2.
—Comparison of Control to Patient Data
| Characteristics | Control | CLE | PLE |
| No. of patients (No. of lungs) | 4 (4) | 4 (4) | 8 (10) |
| Sex, female (male) | 0 (4) | 2 (2) | 3 (5) |
| Age, y | 53.8±4.3 | 60.0±1.6 | 49.6±3.8 |
| Pack-y | 31.5±7.5, n=2 | 43.0±5.5 | 17.9±3.2 |
| FEV1, % pred | N/A | 18.0±2.7 | 19.0±1.6 |
| FEV1/FVC | N/A | 26.8±2.9 | 32.6±2.3 |
| Total lung volume, % predicted | N/A | 137.0±3.6 | 140.1±4.1 |
| Lung volume, mL | 3,251±261 | 3,456±602 | 3,794±595 |
| Lung mass, g | 332±11 | 358±27 | 394±41 |
| No. of terminal bronchioles/mL | 6.9±1.2 | 0.7±0.1 | 1.6±0.5 |
| Total no. of terminal bronchioles | 22,300±3,900 | 2,400±600 | 6,200±2,100, n=7 |
| Average terminal bronchioles cross-sectional area, mm2 | 0.145±0.025 | 0.004±0.002 | 0.047±0.012 |
| Minimum terminal bronchiole lumen diameter, μm | 424.0±48.0 | 51.8±30.0 | 210.2±48.0 |
| Total terminal bronchiole cross-sectional area, mm2 | 3,050.3±576.6 | 7.7±5.1 | 514.1±181.9, n=7 |
CLE=centrilobular emphysema; N/A=not available; PLE=panlobular emphysema associated with α1-antitrypsin deficiency. (Adapted with permission from McDonough et al.9)