FIG. 1.

MiR-137 was down-expressed in glioma tissues and glioma cell lines. (A) The expression of miR-137 in glioma tissues was measured by real-time polymerase chain reaction assay, and six normal brain tissues were counted as a control. MiR-137 expressing level in normal brain tissues were indeed higher than in glioma specimens, and significantly decreased with the ascending of tumor pathological grades. (B) The expression of miR-137 was showed in glioma cell lines LN229, U251, U87, U373, and TJ905. (C, D) MiR-137 mimics could effectively activate the expression of miR-137 in LN229 and U251glioma cells. **p<0.01, compared with the control.