FIG. 3.
Relationship between genomic responses initiated by mCCI and mFPI injuries. Microarray data (cutoff at log2 [TBI/sham]=± 0.5) from the 3- and 24-h postinjury data sets were sorted to identify the intersection of regulated genes (184 and 137 genes in the 3- and 24-h data sets, respectively). Data were plotted as the change in signal intensities (log2) and analyzed using Spearman's rank-order correlation. Significant correlations between mCCI and mFPI responses were found for both the 3- (rs=0.921; p=2×10−7) and 24-h (rs=0.942; p=2×10−7) time points. Slopes for plotted data are 1.519 and 1.489, respectively. Dashed line indicates a theoretical plot with slope=1.000. mCCI, mild controlled cortical impact; mFPI, mild fluid percussion injury.