FIG. 5.

mCCI and mFPI affect levels of multiple mRNAs involved in the IL-6-signaling pathway at 3 h postinjury. Three-hour postinjury microarray data were analyzed using IPA software (Ingenuity Systems, Redwood City, CA, http://www.ingenuity.com). Multiple elements within the IL-6-signaling pathway were significantly enriched in the submitted data sets. Representations of significantly regulated genes within the IL-6-signaling pathway at 3 h post-mCCI (A; p=3.66×10⁻⁶ by Fisher's exact test with Benjamini and Hochberg's correction for multiple testing) and 3 h post-mFPI (B; overall pathway significance: p=2.43×10⁻² by Fisher's exact test with Benjamini and Hochberg's correction for multiple testing). Red indicates up-regulated genes, whereas down-regulated genes are depicted in green. Darker and lighter shading correlates with higher and lower magnitudes of change, respectively. The presented figure was adapted from the IPA pathway. Pathway branches that did not contain genes with significantly altered expression levels after injury were removed. mCCI, mild controlled cortical impact; mFPI, mild fluid percussion injury; mRNAs, messenger RNAs; IL, interleukin; IPA, Ingenuity Pathways Analysis. Color image is available online at www.liebertpub.com/neu