FIG. 6.

I_K and I_A in hiPS and ES cell-derived neurons. I_K and I_A were recorded in neuron-like cells firing abortive, single, multiple, and repetitive APs. (A, B) I_K and very tiny I_A can be recorded in hiPS cell-derived neurons firing abortive and single APs. I_K and I_A were evoked and measured as described in Fig. 5. (C, D) Both I_K and I_A (indicated by their peak component) can be substantially obtained in mature neurons able to fire multiple and repetitive APs. (E) Current density of I_K and I_A in hiPS cell-derived neurons firing different APs. (F) Current density of I_K and I_A in human ES cell-derived neurons firing different APs. *P<0.05; **P<0.01, comparing the correlated groups as indicated. n=5–12 in each group.