FIG. 8.

K⁺ channel activities in mouse stem cell-derived neurons. I_K and I_A in mouse iPS and ES cell-derived neurons firing single and multiple APs. (A, B) I_K and very small I_A can be recorded in mouse iPS and ES cell-derived neurons firing single APs. I_K and I_A were evoked and measured as described in Fig. 5. (C, D) Both I_K and I_A (indicated by their peak component) can be substantially obtained in mouse neurons able to fire multiple APs. (E) Current density of I_K and I_A in mouse iPS cell-derived neurons firing different APs. (F) Current density of I_K and I_A in mouse ES cell-derived neurons firing different APs. *P<0.05, comparing the correlated groups as indicated. n=4–12 in each group.