Table 1.
Four Types of APs Obtained in hiPS and ES Cell-Derived Neurons
AP type | Peak amplitude (mV) | Upstroke slope (mV/ms) | ½ AP width (ms) | Firing frequency (Hz) |
---|---|---|---|---|
Abortive APs | 38.78±10.23# | 6.03±1.75# | 11.71±3.54* | 1 |
Single APs | 65.28±7.86 | 18.49±2.90 | 7.47±1.03 | 1 |
Multiple APs | 61.29±5.36 | 14.93±6.81 | 10.56±4.76 | 4.00±1.53 |
Repetitive APs | 63.09±3.26 | 22.59±3.15§ | 6.16±1.41§ | 15.44±2.35 |
P<0.01, abortive APs compared to the 3 other AP types. *P<0.01, abortive APs compared to single and repetitive APs. §P<0.05, repetitive APs compared to single and multiple APs. Mean±SEM. n=16–34 cells in each group.
APs, action potentials; iPS, induced pluripotent stem; ES, embryonic stem.