Table 2.
Subtype-Specific Analysis of Concordance, Sensitivity, and Specificity Against Trofile Comparing Subtypes B versus A, C, and D
| Subtype | N | Trofile DM/X4 (N) | Trofile R5 (N) | Concordance with Trofile | Sensitivity for non-R5 | Specificity for non-R5 | |
|---|---|---|---|---|---|---|---|
| Population sequencing | |||||||
| g2p[coreceptor] cutpoint fpr 5.75% | Ba | 1,859 | 688 | 1,171 | 81.3% | 65.6% | 90.5% |
| All non-B | 260 | 107 | 153 | 84.2% | 78.5% | 88.2%b | |
| A | 78 | 9 | 69 | 91.0% | 44.4%b | 97.1% | |
| C | 95 | 55 | 40 | 86.3% | 80.0% | 95.0% | |
| D | 87 | 43 | 44 | 75.9%b | 83.7% | 68.2%b | |
| g2p[coreceptor] cutpoint fpr 10% | Ba | 1,859 | 688 | 1,171 | 78.6% | 74.0% | 81.4% |
| All non-B | 260 | 107 | 153 | 81.5% | 83.2% | 80.4%b | |
| A | 78 | 9 | 69 | 85.9% | 55.6%b | 89.9% | |
| C | 95 | 55 | 40 | 86.3% | 83.6% | 90.0% | |
| D | 87 | 43 | 44 | 72.4%b | 88.4% | 56.8%b | |
| 454 “deep” sequencing | |||||||
| g2p[454] | Ba | 1,823 | 665 | 1,158 | 82.3% | 80.0% | 83.6% |
| All non-B | 280 | 125 | 155 | 86.8% | 92.0% | 82.6%b | |
| A | 85 | 12 | 73 | 85.9% | 83.3% | 86.3% | |
| C | 104 | 65 | 39 | 95.2% | 95.4% | 94.9% | |
| D | 91 | 48 | 43 | 78.0%b | 89.6% | 65.1%b | |
a
Subtype B data are obtained from MOTIVATE/1029 studies.
b
Represents a decrease from subtype B.