Table 1. Modulation of chemotherapeutic efficacy by UPR activity.
Agent | Mechanism of action | UPR | Reference(s) |
---|---|---|---|
Etoposide | Topoisomerase inhibitor | Antagonizes | (140) |
Doxorubicin | Topoisomerase inhibitor | Antagonizes | (140, 144) |
Camptothecin | Topoisomerase inhibitor | Antagonizes | (145) |
Cisplatin | DNA/protein cross-linker | Synergizes | (146, 147) |
Melphalan | DNA/protein cross-linker | Synergizes | (146) |
BCNU | DNA/protein cross-linker | Synergizes | (146) |
Bortezomib (Velcade) | Proteasome inhibitor | Inhibits UPR? | (136) |
Activates PERK | (137) | ||
Activates GCN2 | (138) | ||
Combretastatin A4 | Antivascular | Induces GRP78 | (148) |
Contortrostatin | Anti-angiogenesis | Induces GRP78 | (148) |
Imatinib (Gleevec) | BCR-Abl kinase inhibitor | Induces UPR | (149) |