Table 2. Serial Results of Prenatal and Postnatal Imaging and EUA.
Patient | Family History | Fetal DNA | U/S No. 1 | U/S No. 2 | U/S No. 3 | U/S No. 4 | U/S No. 5 | U/S No. 6 | MRI No. 1 | MRI No. 2 | MRI No. 3 | EUA | Postnatal MRI |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Mother | − | 18 wk, no tumor | 20 wk, no tumor | 22 wk, no, tumor | NA | NA | NA | 22 wk, no tumor | NA | NA | No tumor | Not done |
2 | Mother | + | 15 wk, no tumor | 19 wk, no tumor | 25 wk, no tumor | 33 wk, no tumor | 35 wk, no tumor | 37 wk, left retina elevated, tumor 2 mm | 19 wk, no tumor | 28 wk, no tumor, dacryocystocele | 36 wk, no tumor, dacryocystocele | 2mos old, R: minimally elevated tumors ×2, L: 2-mm elevated tumor | 5 mo old (after treatment), no tumor |
3 | Half-sister with bilateral Rb | Not done | 24 wk, no tumor, orbits 5%, micro | 28 wk, no tumor, orbits 5%, micro | 33 wk, no, tumor, orbits 5%, micro | 37 wk, no, tumor, orbits 5–50%, micro | Not done | Not done | 22 wk, globes 18–20 wk | 28 wk, globes, 25–26 wk | 36 wk, globes, 31–32 wk | No tumor | Not done |
4 | Father's siblings' children (8) and father with unilateral Rb | Not done | 37 wk, no tumor | Not done | Not done | Not done | Not done | Not done | 38 wk, no tumor | Not done | Not done | No tumor | Not done |
5 | Sister with bilateral Rb and father with Rb | Not done | 17 wk, no tumor | 25 wk, no tumor | 37 wk, no tumor | Not done | Not done | Not done | 39 wk, no tumor | Not done | Not done | No tumor | Not done |
6 | Brother with Rb (determined later to be unilateral), patient with gastroschisis | Not done | 22 wk, no tumor | 27 wk, no tumor | 31 wk, no tumor | 34 wk, no tumor | 35 wk, no tumor | 36 wk, no tumor | 36 wk, no tumor | Not done | Not done | No tumor | Not done |
EUA, ophthalmologic exam under anesthesia; L, left; MRI, fetal magnetic resonance imaging; N/A, not applicable; R, right; U/S, prenatal ultrasound.