Table 2.
Longitudinal association of marker levels with disease activity using the Birmingham Vasculitis Activity Score for Wegener’s Granulomatosis (BVAS/WG). Results expressed as increase in disease activity score on the BVAS/WG per unit-increase in log-marker level.
| Marker | Crude Association | Adjusted for CRP | Adjusted for PR3-ANCA | Adjusted for All Markers | ||||
|---|---|---|---|---|---|---|---|---|
| β Estimate (95% CI) | Std β | β Estimate (95% CI) | Std β | β Estimate (95% CI) | Std β | β Estimate (95% CI) | Std β | |
| sCD40L | 0.83 (0.42, 1.25) | 0.19 | 0.81 (0.39, 1.24) | 0.19 | 0.83 (0.44, 1.22) | 0.20 | 0.66 (0.24, 1.07) | 0.16 |
| CRP | 0.28 (0.09, 0.47) | 0.10 | — | 0.28 (0.09, 0.47) | 0.11 | −0.02 (−0.26, 0.21) | −0.01 | |
| IL-6 | 0.16 (−0.40, 0.72) | 0.02 | 0.01 (−0.61, 0.62) | 0.00 | 0.07 (−0.49, 0.64) | 0.01 | 0.69 (−0.06, 1.44) | 0.11 |
| IL-8 | 0.79 (0.45, 1.13) | 0.19 | 0.69 (0.35, 1.03) | 0.17 | 0.86 (0.51, 1.21) | 0.21 | 0.93 (0.46, 1.41) | 0.23 |
| MCP-1 | −0.66 (−1.09, −0.24) | −0.13 | −0.86 (−1.28, −0.44) | −0.17 | −0.62 (−1.05, −0.19) | −0.13 | −1.49 (−2.05, −0.93) | −0.31 |
| P-selectin | 0.81 (0.48, 1.15) | 0.17 | 0.67 (0.32, 1.02) | 0.14 | 0.82 (0.47, 1.17) | 0.17 | 0.46 (0.06, 0.86) | 0.10 |
| VEGF | 0.33 (0.09, 0.58) | 0.09 | 0.30 (0.04, 0.55) | 0.08 | 0.35 (0.09, 0.61) | 0.10 | −0.08 (−0.45, 0.29) | −0.02 |
| PR3-ANCA | 0.80 (0.44, 1.16) | 0.17 | 0.73 (0.35, 1.12) | 0.16 | — | 0.71 (0.26, 1.16) | 0.16 | |
sCD40L: soluble CD40 ligand; CRP: C-reactive protein; IL: interleukin; MCP-1: monocyte chemoattractant protein 1; VEGF: vascular endothelial growth factor; PR3-ANCA: antiproteinase 3 antineutrophil cytoplasmic antibody Std β: standardized β estimate.