Table 2.
Association of SNPs with P<0.05 for sensitization to allergens in the Swedish population
| Gene | SNP ID | Chromosome position |
Kruskal-Wallis test |
||||
|---|---|---|---|---|---|---|---|
| Birch | Timothy | ||||||
|
IL10 |
rs3024498 |
1 |
206941529 |
0.27 |
(0.95) |
0.0094 |
(0.31) |
|
IL10 |
rs3024492 |
1 |
206944112 |
0.17 |
(0.87) |
0.025 |
(0.36) |
|
IL13 |
rs20541 |
5 |
131995964 |
0.00040 |
(0.038) |
0.58 |
(0.77) |
|
IL13 |
rs848 |
5 |
131996500 |
0.00067 |
(0.043) |
0.56 |
(0.77) |
|
IL4 |
rs2243248 |
5 |
132008644 |
0.0044 |
(0.21) |
0.52 |
(0.76) |
|
IL4 |
rs2070874 |
5 |
132009710 |
0.051 |
(0.87) |
0.016 |
(0.31) |
|
IL4 |
rs2227284 |
5 |
132012725 |
0.015 |
(0.57) |
0.18 |
(0.59) |
|
IL4 |
rs2243266 |
5 |
132013789 |
0.046 |
(0.87) |
0.014 |
(0.31) |
|
IL4 |
rs2243288 |
5 |
132017944 |
0.046 |
(0.87) |
0.013 |
(0.31) |
|
SPINK5 |
rs4357026 |
5 |
147457939 |
0.77 |
(0.99) |
0.048 |
(0.45) |
|
SPINK5 |
rs9325073 |
5 |
147498652 |
0.90 |
(0.99) |
0.020 |
(0.31) |
|
SPINK5 |
rs1422993 |
5 |
147503820 |
0.96 |
(0.99) |
0.015 |
(0.31) |
|
SPINK5 |
rs4263489 |
5 |
147516195 |
0.049 |
(0.87) |
0.61 |
(0.77) |
|
LTC4S |
rs730012 |
5 |
179220638 |
0.042 |
(0.87) |
0.57 |
(0.77) |
|
NPSR1 |
rs323917 |
7 |
34741643 |
0.048 |
(0.87) |
0.35 |
(0.63) |
|
NPSR1 |
rs12534369 |
7 |
34804709 |
0.64 |
(0.96) |
0.033 |
(0.43) |
|
NPSR1 |
rs17170017 |
7 |
34874209 |
0.54 |
(0.95) |
0.011 |
(0.31) |
|
N.D. |
rs10897270 |
11 |
62183007 |
0.90 |
(0.99) |
0.012 |
(0.31) |
|
GSTP1 |
rs1138272 |
11 |
67353579 |
0.00022 |
(0.038) |
0.20 |
(0.61) |
|
NOS1 |
rs6490121 |
12 |
117708195 |
0.33 |
(0.95) |
0.036 |
(0.44) |
|
NOS1 |
rs12578547 |
12 |
117763347 |
0.091 |
(0.87) |
0.018 |
(0.31) |
|
NOS1 |
rs3782218 |
12 |
117771511 |
0.96 |
(0.99) |
0.046 |
(0.45) |
|
NOS1 |
rs17509231 |
12 |
117794323 |
0.43 |
(0.95) |
0.011 |
(0.31) |
| IL4R | rs1029489 | 16 | 27376217 | 0.46 | (0.95) | 0.039 | (0.44) |
Association between genotype and sensitization to allergens was analyzed using a Kruskal-Wallis rank sum test. False discovery rate was quantified using the q-value introduced by Storey(2002) and are given in parenthesis.