Table 4.
Association of SNPs with P<0.05 for sensitization to allergens in the Chinese population
| Gene | SNP ID | Chromosome position |
Kruskal-Wallis test |
||||
|---|---|---|---|---|---|---|---|
| B.tropicalis | D. pteronyssinus | ||||||
|
SPINK5 |
rs10477360 |
5 |
147384474 |
0.027 |
(0.65) |
0.69 |
(1.0) |
|
ADRB2 |
rs2163752 |
5 |
148125331 |
0.027 |
(0.65) |
0.054 |
(0.92) |
|
ADRB2 |
rs30306 |
5 |
148132557 |
0.028 |
(0.65) |
0.074 |
(0.97) |
|
ADRB2 |
rs30325 |
5 |
148143517 |
0.27 |
(0.82) |
0.010 |
(0.52) |
|
ADRB2 |
rs30328 |
5 |
148146640 |
0.28 |
(0.82) |
0.025 |
(0.75) |
|
ADRB2 |
rs30330 |
5 |
148148525 |
0.32 |
(0.82) |
0.027 |
(0.75) |
|
ADRB2 |
rs9285673 |
5 |
148153121 |
0.049 |
(0.78) |
0.90 |
(1.0) |
|
ADRB2 |
rs10075995 |
5 |
148273622 |
0.53 |
(0.82) |
0.014 |
(0.52) |
|
NPSR1/AAA1 |
rs2058163 |
7 |
34301616 |
0.049 |
(0.78) |
0.025 |
(0.75) |
|
NPSR1/AAA1 |
rs1419842 |
7 |
34321625 |
0.41 |
(0.82) |
0.031 |
(0.75) |
|
NPSR1/AAA1 |
rs2392268 |
7 |
34380952 |
0.44 |
(0.82) |
0.031 |
(0.75) |
|
NPSR1/AAA1 |
rs6947789 |
7 |
34417405 |
0.018 |
(0.65) |
0.83 |
(1.0) |
|
NPSR1/AAA1 |
rs736295 |
7 |
34417742 |
0.054 |
(0.79) |
0.039 |
(0.75) |
|
NPSR1 |
rs2530545 |
7 |
34663665 |
0.94 |
(0.90) |
0.040 |
(0.75) |
|
NPSR1 |
rs11761197 |
7 |
34666914 |
0.78 |
(0.90) |
0.013 |
(0.52) |
|
NPSR1 |
rs1379928 |
7 |
34667814 |
0.51 |
(0.82) |
0.0098 |
(0.52) |
|
NPSR1 |
rs2609224 |
7 |
34672931 |
0.62 |
(0.85) |
0.011 |
(0.52) |
|
NPSR1 |
rs2609220 |
7 |
34676579 |
0.68 |
(0.86) |
0.0067 |
(0.52) |
|
NPSR1 |
rs2531841 |
7 |
34686074 |
0.81 |
(0.90) |
0.012 |
(0.52) |
|
NPSR1 |
rs1419837 |
7 |
34692064 |
0.88 |
(0.90) |
0.018 |
(0.62) |
|
NPSR1 |
rs1419779 |
7 |
34779833 |
0.21 |
(0.82) |
0.0011 |
(0.15) |
|
NPSR1 |
rs324978 |
7 |
34780857 |
0.20 |
(0.82) |
0.00098 |
(0.15) |
|
NPSR1 |
rs1859409 |
7 |
34906409 |
0.049 |
(0.78) |
0.83 |
(1.0) |
|
NPSR1 |
rs4723388 |
7 |
34909345 |
0.0056 |
(0.51) |
0.52 |
(0.98) |
|
NPSR1 |
rs1186717 |
7 |
34937434 |
0.33 |
(0.82) |
0.036 |
(0.75) |
|
NPSR1 |
rs1637673 |
7 |
34964375 |
0.15 |
(0.82) |
0.0081 |
(0.52) |
|
NPSR1 |
rs4236340 |
7 |
34976719 |
0.0061 |
(0.51) |
0.46 |
(0.98) |
|
NPSR1 |
rs328902 |
7 |
34987368 |
0.41 |
(0.82) |
0.038 |
(0.75) |
|
NPSR1 |
rs328906 |
7 |
34990440 |
0.0080 |
(0.51) |
0.58 |
(0.98) |
|
NPSR1 |
rs2023328 |
7 |
34998155 |
0.0053 |
(0.51) |
0.60 |
(0.98) |
|
NPSR1 |
rs329240 |
7 |
35024965 |
0.41 |
(0.82) |
0.038 |
(0.75) |
|
MS4A2 |
rs540170 |
11 |
59636614 |
0.049 |
(0.78) |
0.98 |
(1.0) |
|
MS4A2 |
rs581133 |
11 |
59638882 |
0.043 |
(0.78) |
0.99 |
(1.0) |
|
NOS1 |
rs1093325 |
12 |
116179703 |
0.031 |
(0.7) |
0.23 |
(0.98) |
|
NOS1 |
rs1004356 |
12 |
116261755 |
0.026 |
(0.65) |
0.43 |
(0.98) |
|
IL4R |
rs3024585 |
16 |
27267345 |
0.0036 |
(0.51) |
0.98 |
(1.0) |
|
IL4R |
rs1805011 |
16 |
27281373 |
0.011 |
(0.51) |
0.076 |
(0.97) |
|
IL4R |
rs1805012 |
16 |
27281465 |
0.011 |
(0.51) |
0.076 |
(0.97) |
|
IL4R |
rs1805015 |
16 |
27281681 |
0.022 |
(0.65) |
0.11 |
(0.97) |
|
IL4R |
rs3024685 |
16 |
27284411 |
0.045 |
(0.78) |
0.21 |
(0.98) |
|
IL4R |
rs4787956 |
16 |
27285750 |
0.0087 |
(0.51) |
0.17 |
(0.97) |
|
IL4R |
rs4787426 |
16 |
27292232 |
0.026 |
(0.65) |
0.37 |
(0.98) |
|
ADAM33 |
rs512625 |
20 |
3596378 |
0.017 |
(0.65) |
0.22 |
(0.98) |
| ADAM33 | rs2853210 | 20 | 3606211 | 0.046 | (0.78) | 0.0010 | (0.15) |
Association between genotype and sensitization to allergens was analyzed using a Kruskal-Wallis rank sum test. False discovery rate was quantified using the q-value introduced by Storey(2002) and are given in parenthesis.