Figure 1.

COG classification of differentially expressed genes during exposure to bile salts. The down-regulated (left two columns) and up-regulated (right two columns) genes during bile treatment were grouped by COG functional categories, respectively, and the percentage abundance of each group was compared to abundance of each COG in the E1162 genome. The one-letter codes represent the following COG functional categories: C: energy production and conversion; D: cell cycle control, cell division, chromosome partitioning; E: amino acid transport and metabolism; F: nucleotide transport and metabolism; G: carbohydrate transport and metabolism; H: coenzyme transport and metabolism; I: lipid transport and metabolism; J: translation, ribosomal structure and biogenesis; K: transcription; L: replication, recombination and repair; M: cell wall/membrane/envelope biogenesis; N: cell motility; O: posttranslational modification, protein turnover; chaperones; P: inorganic ion transport and metabolism; Q: secondary metabolites biosynthesis, transport and catabolism; R: general function prediction only; S: function unknown; T: signal transduction mechanisms; U: intracellular trafficking, secretion, and vesicular transport; V: defense mechanisms.